Christina Applegate talks struggle to film 'Dead to Me' with MS: 'I can't walk without a cane'

Christina Applegate is getting candid about her battle with multiple sclerosis and sharing what it was like to film the third and final season of "Dead to Me" amid the emotional and physical toll of the disease.

"I put on 40 pounds; I can’t walk without a cane," Applegate said in an interview with the New York Times as a disclaimer to the upcoming season of her Netflix hit. "I want people to know that I am very aware of all of that."

Season 3 of "Dead to Me," which premieres Nov. 17, was delayed due to the COVID-19 pandemic and Applegate's diagnosis. At one point, production considered halting altogether, but the actress felt an "an obligation" to creator Liz Feldman and her co-star Linda Cardellini.

"I said, 'No. We’re going to do it, but we’re going to do it on my terms,'" Applegate recalled to the outlet.

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With MS, the body's immune system begins attacking the central nervous system, according to the National Multiple Sclerosis Society, triggering various neurological symptoms.

The Emmy winner was still learning how to adapt to the changes of her body while filming. She used a wheelchair to get around set and even had crew members hold her legs up from the floor during some standing scenes, according to the NYT.

Applegate noted that she probably won't watch the season due to the difficulties she experienced while filming, but hopes people are able to "get past" what she feels are noticeable changes.

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"If people hate it, if people love it, if all they can concentrate on is, ‘Ooh, look at the cripple,’ that’s not up to me," Applegate said. "I’m sure that people are going to be, like, 'I can’t get past it.'"

Netflix released a new trailer Wednesday ahead of the series finale premiere.

"We've been through a lot already and we survived because we had each other," Cardenelli's character Judy Hale says as flashbacks play. Jen Harding (Applegate) then corrects to "have each other."

The trailer suggests Judy is about to be discovered as the hit-and-run driver who killed Jen's husband. At the end, Jen declares, "Jude, we're in this together."

Applegate, 50, went public with her MS diagnosis in August 2021, which she told her Twitter followers she'd received "a few months" earlier. "It’s been a strange journey," Applegate wrote at the time. "But I have been so supported by people that I know who also have this condition."

Contributing: Erin Jensen, Hannah Yasharoff

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This article originally appeared on USA TODAY: Christina Applegate: MS made filming 'Dead to Me' Season 3 a struggle