ER Cast: Then and Now

ER was a pivotal piece of NBC’s Must-See TV lineup from 1994-2009, airing Thursdays at 10/9c for the entirety of its run. It amassed a record-setting 124 Emmy nominations, winning a total of 23 Emmys, including one for Outstanding Drama Series.

On Thursday, April 22, the original cast (along with a few later additions) will come together for a virtual reunion — which you catch watch here.

More from TVLine

• May TV Calendar: 115+ Finales, Series Finales, Premieres, Returns and More

• Julianna Margulies Tells Oprah Why She Quit ER in Season 6 -- Despite a $27 Million Offer to Stay (Watch Video)

• The Voice Recap: As the Knockouts Conclude, Down for the Count Go Four Singers, Including an Early Frontrunner

Up until 2019, when it was upstaged by ABC’s Grey’s Anatomy, ER‘s 331 episodes made it TV’s longest-running medical drama. While a revival is not currently in the works, executive producer John Wells has said that he’d be open to a revival if “a really interesting idea” came along.

Scroll down to see photos of the series’ original six cast members, then and now…

Best of TVLine

• TV Ships We Can't Believe Never Kissed

• Best TV Vampires, Ranked: 23 Fanged Favorites From TVD, True Blood, Buffy, Angel, Shadowhunters and More

• The Brady Bunch Characters, Ranked — Somewhat Brutally at Times

Get more from TVLine.com: Follow us on Twitter, Facebook, Newsletter